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Rabbit Anti-MARCO  antibody (bs-2659R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-2659R
英文名称 MARCO
中文名称 巨噬细胞清道夫受体抗体
别    名 Macrophage receptor MARCO; Marco; MARCO_HUMAN; Macrophage receptor with collagenous structure; SCARA2; Scavenger receptor class A member 2.  
Specific References  (2)     |     bs-2659R has been referenced in 2 publications.
[IF=12.57] Li, Hao, et al. "Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus." The Journal of clinical investigation 125.7 (2015): 2877.  IHC-P ;  Human.  
[IF=3.329] Xiao Y et al. Down-regulation of MARCO associates with tumor progression in hepatocellular carcinoma. Exp Cell Res. 2019 Aug 2:111542.  WB&IHC-P ;  Human.  
研究领域 细胞生物  免疫学  微生物学  细菌及病毒  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,Mouse,GuineaPig (predicted: Rat,Chicken,Dog)
产品应用 WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 53kDa
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MARCO: 421-520/520 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq].

Function:
Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.

Subunit:
Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands.

Subcellular Location:
Membrane; Single-pass type II membrane protein.

Similarity:
Contains 1 collagen-like domain.
Contains 1 SRCR domain.

SWISS:
Q9UEW3

Gene ID:
8685

Database links:

Entrez Gene: 8685 Human

Omim: 604870 Human

SwissProt: Q9UEW3 Human

Unigene: 67726 Human



产品图片
Tissue/cell: mouse lung tissue;4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-MARCO Polyclonal Antibody, Unconjugated(bs-2659R-FITC) 1:100, overnight at 4°C; DAPI(5ug/ml,blue,C-0033) was used to stain the cell nuclei
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