| 产品编号 | bs-2616R |
| 英文名称 | IL18R Beta Rabbit pAb |
| 中文名称 | 白细胞介素-18受体β链抗体 |
| 别 名 | ACPL; CD218b; CDw218b; IL-18R-beta; IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB; I18RA_HUMAN; IL18RAP; IL-18 receptor accessory protein; Accessory protein-like (AcPL); CD218 antigen-like family member B; IL-1R accessory protein-like (IL-1RAc |
 |
Specific References (3) | bs-2616R has been referenced in 3 publications.
[IF=4.3] Valente, Anthony J., et al. "Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin." Cellular Signalling (2013). IP ; Human.
[IF=3.487] Valente et al. Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin. (2013) Cell.Signal. 25:1447-56 IP,WB ; Human.
[IF=2.903] Dou Y et al. The Riemerella anatipestifer M949_RS01035 gene is involved in bacterial lipopolysaccharide biosynthesis. Vet. Res. (2018) Sep 17 ;49(1) IP,WB ; Human.
|
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | Human |
| 产品应用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 68 kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL-18R beta: 15-120/599 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
IL18R Beta is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and IL18R Beta is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. Function: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Subunit: Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells. Similarity: Belongs to the interleukin-1 receptor family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 TIR domain. SWISS: O95256 Gene ID: 8807 Database links: Entrez Gene: 8807 Human Entrez Gene: 16174 Mouse Omim: 604509 Human SwissProt: O95256 Human SwissProt: Q9Z2B1 Mouse Unigene: 158315 Human Unigene: 20466 Mouse Unigene: 392521 Mouse |
| 产品图片 |
Sample:Spleen (Mouse)Lysate at 40 ug
Primary: Anti-IL18R Beta(bs-2616R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 68kD
Observed band size: 68kD
Sample:
Lane 1: Human U937 cell lysates
Lane 2: Human HL60 cell lysates
Lane 3: Human A549 cell lysates
Lane 4: Human Du145 cell lysates
Primary: Anti- IL18R Beta (bs-2616R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 68 kD
Observed band size: 66 kD
|
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
