| 产品编号 | bs-2601R |
| 英文名称 | IL5RA |
| 中文名称 | 白介素-5受体α链抗体IL-5Rα |
| 别 名 | Interleukin-5 receptor alpha; CD125 antigen; CDw125; HSIL5R3; IL5R; IL-5R; Interleukin 5 Receptor alpha; Interleukin 5 receptor subunit alpha; interleukin 5 receptor type 3; MGC26560; IL5RA; IL-5R alpha; IL5RA_HUMAN. |
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Specific References (3) | bs-2601R has been referenced in 3 publications.
[IF=5.085] Venosa Alessandro. et al. Role of CCR2+ Myeloid Cells in Inflammation Responses Driven by Expression of a Surfactant Protein-C Mutant in the Alveolar Epithelium. Front Immunol. 2021 Apr;12:1348 IHC ; Mouse.
[IF=4.344] Gitto SB et al. Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells. Cell Commun Signal. 2020 Jun 17;18(1):95. ICF&IHC-P ; Mouse&Human.
[IF=2.55] Chen, Yanyan, et al. "Catalpol alleviates ovalbumin-induced asthma in mice: Reduced eosinophil infiltration in the lung." International Immunopharmacology 43 (2017): 140-146. WB ; Mouse.
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| 研究领域 | 细胞生物 免疫学 转录调节因子 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human,Mouse (predicted: Rat,Cow,Rabbit) |
| 产品应用 | WB=1:500-2000, ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 46kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL-5R alpha: 11-110/420 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3(IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5(IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. Function: This is the receptor for interleukin-5. The alpha chain binds to IL5. Subunit: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Interacts with SDCBP. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed on eosinophils and basophils. Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily. SWISS: Q01344 Gene ID: 3568 Database links: Entrez Gene: 3568 Human Entrez Gene: 16192 Mouse Omim: 147851 Human SwissProt: Q01344 Human SwissProt: P21183 Mouse Unigene: 207105 Human Unigene: 68876 Human Unigene: 3448 Mouse |
| 产品图片 |
Sample:
testis (mouse) Lysate at 40 ug lung (mouse) Lysate at 40 ug ovary (mouse) Lysate at 40 ug A549 (human)cell Lysate at 40 ug Primary: Anti- IL5RA(bs-2061R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 46kD Observed band size: 56 kD |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
