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Rabbit Anti-CCL27 antibody (bs-2484R)
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-2484R
英文名称 Rabbit Anti-CCL27 antibody
中文名称 皮肤T细胞虏获趋化因子抗体
别    名 ALP; CTACK; C-C motif chemokine 27; CC chemokine ILC; Ccl27; CTAK; Cutaneous T cell attracting chemokine; Cutaneous T-cell-attracting chemokine; ESkine; IL 11 R alpha locus chemokine; IL-11 R-alpha-locus chemokine; PESKY; SCYA27; Skinkine; Small inducible cytokine A27; Small-inducible cytokine A27.  
研究领域 免疫学  趋化因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human (predicted: Mouse,Rat,Cow)
产品应用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 19kDa
细胞定位 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse CCL27: 25-112/164 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq].

Function:
Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

Subunit:
Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization.

Subcellular Location:
Secreted.

Tissue Specificity:
Testis, thymus, placenta, ovary and skin.

Similarity:
Belongs to the intercrine beta (chemokine CC) family.

SWISS:
Q9Z1X0

Gene ID:
10850

Database links:

Entrez Gene: 10850 Human

Omim: 604833 Human

SwissProt: Q5VZ77 Human

SwissProt: Q9Y4X3 Human

Unigene: 459590 Human

Unigene: 648124 Human



CCL27是一种CC型趋化因子,又被称为Skinkine,ESkine和CTACK。CCL27基因位于人类染色体9,它与皮肤上归巢的记忆T淋巴细胞有关,并在T细胞介导的皮肤炎症中起着重要的作用。CCL27表达在许多组织,包括性腺,胸腺,胎盘和皮肤。其配体为CCR10,CCL27与接触性软疣病毒编码产生的蛋白质MC148有较高的同源性,但却与人疱疹病毒8型编码产生病毒巨噬细胞炎症蛋白-Ⅱ竞争结合受体CCR10。
产品图片
Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CCL27 Polyclonal Antibody, Unconjugated(bs-2484R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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