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Rabbit Anti-CCL14/SCYL2 antibody (bs-2479R)
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价
产品编号 bs-2479R
英文名称 Rabbit Anti-CCL14/SCYL2 antibody
中文名称 嗜酸粒细胞趋化蛋白14抗体
别    名 CAPER; CCL14; CCL14_HUMAN; chemokine (C-C motif) ligand 14; Chemokine CC-1/CC-3; chemokine CC1; chemokine CC3; chemokine HCC1; chemokine HCC3; CKb1; Coactivator of activating protein 1 and estrogen receptors; Coactivator of AP1 and ERs; HCC-1(1-74); HCC-1(9-74); HCC-1/HCC-3; HCC1; HEMOFILTRATE CC CHEMOKINE 1; Hepatocellular carcinoma protein 1; MCIF; NCC-2; NCC2; RNA binding region (RNP1 RRM) containing 2; RNA binding region containing protein 2; RNPC2; SCYA14; SCYL2; Small-inducible cytokine A14; Splicing factor CC1.3; Splicing factor CC1.4; Splicing factor HCC1; SY14; Transcription coactivator CAPER.  
研究领域 肿瘤  免疫学  信号转导  趋化因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human,Rabbit)
产品应用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 8/9kDa
细胞定位 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CCL14: 20-93/93 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq].

Function:
Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.

Post-translational modifications:
The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.
HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.

Similarity:
Belongs to the intercrine beta (chemokine CC) family.

SWISS:
Q16627

Gene ID:
6358

Database links:

Entrez Gene: 6358 Human

Omim: 601392 Human

SwissProt: Q16627 Human

Unigene: 272493 Human

Unigene: 740501 Human



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