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alpha Internexin Rabbit pAb (bs-2408R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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产品编号 bs-2408R
英文名称 alpha Internexin Rabbit pAb
中文名称 α-中连蛋白抗体
别    名 a-Internexin; alpha-Internexin; alpha-Internexin; 66 kDa neurofilament protein; alpha Inx; INA; Internexin neuronal intermediate filament protein alpha; MGC12702; NEF 5; NEF5; Neurofilament 5(66kD); Neurofilament 66; Neurofilament 66 tax binding protein; NF 66; NF66; NF-66; TXBP 1; TXBP1; AINX_HUMAN; alpha-Inx; Neurofilament-66.  
研究领域 神经生物学  干细胞  细胞粘附分子  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human (predicted: Mouse,Rat,Pig,Cow,Dog,Horse)
产品应用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 55 kDa
检测分子量
细胞定位 细胞浆 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NF-66: 251-350/499 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 eurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]

Function:
Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.

Subcellular Location:
Cytoplasmic.

Tissue Specificity:
Found predominantly in adult CNS.

Post-translational modifications:
O-glycosylated (By similarity).
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the intermediate filament family.

SWISS:
Q16352

Gene ID:
9118

Database links:

Entrez Gene: 9118 Human

Entrez Gene: 226180 Mouse

Entrez Gene: 24503 Rat

Omim: 605338 Human

SwissProt: Q16352 Human

SwissProt: P46660 Mouse

SwissProt: P23565 Rat

Unigene: 500916 Human

Unigene: 276251 Mouse

Unigene: 88941 Rat



产品图片
Sample: Lane 1: Human SH-SY5Y cell lysates Lane 2: Human HeLa cell lysates Primary: Anti-alpha Internexin (bs-2408R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kDa Observed band size: 64 kDa
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