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Rabbit Anti-MCP4 antibody (bs-2468R)
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价
产品编号 bs-2468R
英文名称 Rabbit Anti-MCP4 antibody
中文名称 单核细胞趋化蛋白4抗体
别    名 Chemokine (C C motif) ligand 13; CCL13; MCP-4; SCYL1; CK beta 10; CKb10; MGC17134; Monocyte chemoattractant protein 4; Monocyte chemotactic protein 4; NCC 1; NCC1; New CC chemokine 1; SCYA13; SCYL1; Small inducible cytokine A13 precursor; Small inducible cytokine subfamily A (Cys Cys) member 13; CCL13_HUMAN.  
研究领域 肿瘤  细胞生物  免疫学  神经生物学  趋化因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human,Rabbit,Dog)
产品应用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 110kDa
细胞定位 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CCL13: 51-98/98 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq].

Function:
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.

Subcellular Location:
Secreted.

Tissue Specificity:
Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.

Post-translational modifications:
One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.

Similarity:
Belongs to the intercrine beta (chemokine CC) family.

SWISS:
Q99616

Gene ID:
6357

Database links:

Clone ID: BC008621 Human

Entrez Gene: 6357 Human

IMAGE Id: 4184250 Human

Omim: 601391 Human

SwissProt: Q99616 Human

Unigene: 414629 Human



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