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Rabbit Anti-GRM4  antibody (bs-1894R)  
~~~促销,代码KT202502A~~~
~~~促销,代码KT202502B~~~
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订购QQ:  400-901-9800
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-1894R
英文名称 Rabbit Anti-GRM4  antibody
中文名称 促代谢型谷氨酸受体4抗体
别    名 G protein coupled receptor family C group 1 member D; G protein coupled receptor GRM 4; G protein coupled receptor GRM4; Glutamate receptor metabotropic 4; GPRC 1D; GPRC1D; GRM 4; GRM4; GRM4_HUMAN; Metabotropic glutamate receptor 4; mGlu 4; mGlu R4; mGlu4; mGluR 4; mGluR4.  
研究领域 免疫学  神经生物学  细胞凋亡  G蛋白偶联受体  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,Rat (predicted: Human,Rabbit,Pig)
产品应用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 102kDa
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GRM4: 301-400/912 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Function:
Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.

Subunit:
Interacts with PICK1

Subcellular Location:
Cell membrane.

Tissue Specificity:
Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.

Similarity:
Belongs to the G-protein coupled receptor 3 family.

SWISS:
Q14833

Gene ID:
2914

Database links:

Entrez Gene: 2914 Human

Entrez Gene: 268934 Mouse

Entrez Gene: 24417 Rat

Omim: 604100 Human

SwissProt: Q14833 Human

SwissProt: Q68EF4 Mouse

SwissProt: P31423 Rat

Unigene: 429018 Human



产品图片
25 ug total protein per lane of various lysates (see on figure) probed with GRM4 polyclonal antibody, unconjugated (bs-1894R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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