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Rabbit Anti-ODC1  antibody (bs-1294R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-1294R
英文名称 ODC1
中文名称 鸟氨酸脱羧酶抗体
别    名 Ornithine decarboxylase 1; Ornithine decarboxylase; Dodc1; Odc 1; ODC1; ODC2; Ornithine decarboxylase 2; DCOR_HUMAN; Ornithine decarboxylase 1; Ornithine decarboxylase; Ornithine decarboxylase structural 1; RNODC.  
Specific References  (5)     |     bs-1294R has been referenced in 5 publications.
[IF=4.492] Jing Wanget al. Regulatory role of l-proline in fetal pig growth and intestinal epithelial cell proliferation. Anim Nutr . 2020 Dec;6(4):438-446.  WB ;  pig.  
[IF=3.789] Wang, Hongliang. et al. A new 68Ga-labeled ornithine derivative for PET imaging of ornithine metabolism in tumors. AMINO ACIDS. 2023 Feb;:1-12  IHC ;  Mouse.  
[IF=2.83] Chen, Shaokui, et al. "Asparagine improves intestinal integrity, inhibits TLR4 and NOD signaling, and differently regulates p38 and ERK1/2 signaling in weanling piglets after LPS challenge." Innate Immunity (2016): 1753425916664124.  WB ;  Pig.  
[IF=2.48] Rossi et al. Immunohistochemical expression of ornithine decarboxylase, diamine oxidase, putrescine, and spermine in normal canine enterocolic mucosa, in chronic colitis, and in colorectal cancer. (2015) Biomed.Res.In. 2015:172756  IHC ;  dog.  
[IF=1.58] Rossi, Giacomo, et al. "Immunohistochemical Expression of Ornithine Decarboxylase, Diamine Oxidase, Putrescine, and Spermine in Normal Canine Enterocolic Mucosa, in Chronic Colitis, and in Colorectal Cancer." BioMed Research International 2015 (2015).  IHC-P ;  Dog.  
研究领域 肿瘤  信号转导  新陈代谢  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,Rat (predicted: Human,Dog,Pig,Cow,Horse)
产品应用 WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 51kDa
细胞定位 细胞浆 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ODC1: 321-461/461 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Ornithine Decarboxylase (ODC) is the initial and rate limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.

Subunit:
Homodimer.

Post-translational modifications:
S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.

Similarity:
Belongs to the Orn/Lys/Arg decarboxylase class-II family.

SWISS:
Q9BQT8

Gene ID:
4953

Database links:

Entrez Gene: 281365 Cow

Entrez Gene: 4953 Human

Entrez Gene: 18263 Mouse

Entrez Gene: 414408 Pig

Entrez Gene: 24609 Rat

Omim: 165640 Human

SwissProt: P27117 Cow

SwissProt: P11926 Human

SwissProt: P00860 Mouse

SwissProt: P09057 Rat

Unigene: 7133 Cow

Unigene: 467701 Human

Unigene: 34102 Mouse

Unigene: 874 Rat



鸟氨酸脱羧酶为多胺生物合成途径中的第一个限速酶 (催化合成多胺的第一步反应 ,即催化L -鸟氨酸脱羧生成腐胺 ) ,具有超常转变率和对于刺激的迅速反应性。
多胺广泛存在于生物体的各种细胞和组织中 ,是一种重要的代谢调控物质 ,它可直接与DNA相互作用 ,调节DNA构象 ,并参与RNA及蛋白质的合成 ,与细胞增殖、分化密切相关。经研究表明 ,哺乳动物细胞增殖体现出完全的多胺依赖性。ODC主要存在于胞浆中。
产品图片
Sample: Kidney(Mouse) lysate at 30ug;
Primary: Anti-ODC(bs-1294R) at 1:300 dilution;
Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000 dilution;
Predicted band size:51 kD
Observed band size:51 kD
Sample:Liver(Mouse) lysate at 30ug;
Primary: Anti-ODC(bs-1294R) at 1:300 dilution;
Secondary: AP conjugated Goat Anti-Rabbit IgG(bs-0295G-AP) at 1: 5000 dilution;
Predicted band size : 51kD
Observed band size : 51kD
Sample: Kidney(Mouse) lysate at 30ug;
Primary: Anti-ODC(bs-1294R) at 1:300 dilution;
Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000 dilution;
Predicted band size:51 kD
Observed band size:51 kD
Paraformaldehyde-fixed, paraffin embedded (rat liver tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ODC) Polyclonal Antibody, Unconjugated (bs-1294R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat stomach tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ODC) Polyclonal Antibody, Unconjugated (bs-1294R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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