扫码关注公众号           扫码咨询技术支持           扫码咨询技术服务
  
客服热线:400-901-9800  客服QQ:4009019800  技术答疑  技术支持  质量反馈  人才招聘  关于我们  联系我们
产品中心-北京博奥森生物技术有限公司
首页 > 产品中心 > 一抗 > 产品信息
Rabbit Anti-Slco1a1  antibody (bs-0607R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
订购热线:400-901-9800
订购邮箱:sales@bioss.com.cn
订购QQ:  400-901-9800
技术支持:techsupport@bioss.com.cn
说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-0607R
英文名称 Slco1a1
中文名称 溶质载体有机阴离子转运蛋白家族成员1A1抗体
别    名 OATP-1; Organic anion-transporting polypeptide 1; SO1A1_RAT; Sodium-independent organic anion transporter 1; Solute carrier family 21 member 1; Solute carrier organic anion transporter family member 1A1.  
Specific References  (5)     |     bs-0607R has been referenced in 5 publications.
[IF=6.876] Song Guochao. et al. Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway. CLIN SCI. 2023 Apr;137(7):561-577  WB ;  Mouse.  
[IF=5.23] Enoki, Yuki, et al. "Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1." Scientific Reports 6 (2016): 32084.  WB ;  Mouse.  
[IF=3.3] Xu C, Zhu L, Chan T, Lu X, Shen W, et al. (2015) The Altered Renal and Hepatic Expression of Solute Carrier Transporters (SLCs) in Type 1 Diabetic Mice. PLoS ONE 10(3): e0120760.  WB ;  Mouse.  
[IF=2.76] Zhu, Liran, et al. "Saponins extracted from Dioscorea collettii rhizomes regulate the expression of urate transporters in chronic hyperuricemia rats." Biomedicine & Pharmacotherapy 93 (2017): 88-94.  IHC-P ;  Rat.  
[IF=1.585] Pang et al. Gypenosides Inhibits Xanthine Oxidoreductase and Ameliorates Urate Excretion in Hyperuricemic Rats Induced by High Cholesterol and High Fat Food (Lipid Emulsion). (2017) Med.Sci.Monit. 23:1129-1140  IHC-P ;  Rat.  
研究领域 转运蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,Rat
产品应用 WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 74kDa
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rat Slco1a1: 2-90/670 <Cytoplasmic>
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 mediates the transport of sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes

Function:
Mediates the Na(+)-independent transport of organic anions such as bromosulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids.

Subunit:
Binds to PDZK1. Interaction with PDZK1 is required for expression on hepatocyte surface.

Subcellular Location:
Basolateral cell membrane

Tissue Specificity:
Highly expressed in liver and kidney, and at lower levels in brain, lung, skeletal muscle and proximal colon.

Post-translational modifications:
Glycosylated.

Similarity:
Belongs to the organo anion transporter (TC 2.A.60) family.
[SIMILARITY] Contains 1 Kazal-like domain.

SWISS:
P46720

Gene ID:
50572

Database links:

Entrez Gene: 28248 Mouse

Entrez Gene: 50572 Rat

SwissProt: Q9QXZ6 Mouse

SwissProt: P46720 Rat

Unigene: 231253 Rat



产品图片
Sample:
Liver (Mouse) Lysate at 40 ug
Primary: Anti-Slco1a1 (bs-0607R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 74 kD
Observed band size: 73 kD
Tissue/cell: mouse kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-OATP-1/Slco1a1 Polyclonal Antibody, Unconjugated(bs-0607R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
版权所有 2004-2026 www.bioss.com.cn 北京博奥森生物技术有限公司
通过国际质量管理体系ISO 9001:2015 GB/T 19001-2016    认证编号: 00122Q31509R1M/1100
京ICP备05066980号-1         京公网安备110107000727号