| 产品编号 | bs-1031R |
| 英文名称 | IFITM1 Rabbit pAb |
| 中文名称 | 干扰素诱导跨膜蛋白1抗体 |
| 别 名 | 9-27; CD225; DSPA2a; IFI17; LEU13; 1110036C17Rik; Mil-2; Mil2; IFM1_HUMAN; IFITM1; Dispanin subfamily A member 2a (DSPA2a); Interferon-induced protein 17; Interferon-inducible protein 9-27; Leu-13 antigen; IFM1_MOUSE; Fragilis protein 2; Mouse ifitm-like |
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Specific References (1) | bs-1031R has been referenced in 1 publications.
[IF=2.934] Jingying Xieet al. Host antiviral protein IFITM2 restricts pseudorabies virus replication. Virus Res
. 2020 Oct 2;287:198105. WB ; pig.
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| 研究领域 | 肿瘤 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | Human (predicted: Mouse,Rat) |
| 产品应用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 11.7 kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IFITM1: 58-86/125 <Cytoplasmic> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
IFITM1 expression is induced by interferons alpha and gamma and it is thought to play a role in control of cell growth. It is upregulated in several tumor types and may be useful as a tumor biomarker. Function: IFN-induced antiviral protein that mediate cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting the early step(s) of replication. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals. Subunit: Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus. Similarity: Belongs to the CD225 family. SWISS: P13164 Gene ID: 8519 Database links: Entrez Gene: 8519 Human Entrez Gene: 68713 Mouse Omim: 604456 Human SwissProt: P13164 Human SwissProt: Q9D103 Mouse Unigene: 458414 Human Unigene: 175661 Mouse Unigene: 22087 Rat IFITM1蛋白是蛋白复合物的组分之一,主要功能是参与同型粘附和抗增殖信号的转导,与细胞增殖、肿瘤分化、抗病毒、免疫监视等有关。IFITM-1主要用于消化系统肿瘤方面的研究，有学者认为：干扰素诱导跨膜蛋白1与干扰素结合，可以抑制肿瘤细胞的分化和增值。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
