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Rabbit Anti-TNFRSF10A  antibody (bs-0591R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
订购热线:400-901-9800
订购邮箱:sales@bioss.com.cn
订购QQ:  400-901-9800
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说明书: 50ul  100ul  
50ul/1180.00元
100ul/1980.00元
大包装/询价

产品编号 bs-0591R
英文名称 TNFRSF10A
中文名称 死亡受体4抗体
别    名 TR10A_HUMAN; Tumor necrosis factor receptor superfamily member 10A; APO2; DR4; TRAILR1; Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1 (TRAIL receptor 1; TRAIL-R1); CD261;  
Specific References  (2)     |     bs-0591R has been referenced in 2 publications.
[IF=7.129] Furui Han. et al. In vivo and in vitro study on hepatotoxicity of Tris-(2, 3-dibromopropyl) isocyanurate exposure via mitochondrial and death receptor pathway. ECOTOX ENVIRON SAFE. 2022 Nov;246:114186  WB ;  Rat, Human.  
[IF=3.752] Zhao Zhang. et al. Effect of matrine in MAC-T cells and their transcriptome analysis: A basic study. PLOS ONE. 2023 Jan;18(1):e0280905  WB ;  Bovine.  
研究领域 细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human
产品应用 WB=1:200-500, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 50kDa
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TNFRSF10A: 401-468/468 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]

Function:
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

Subunit:
Can interact with TRADD and RIPK1. Interacts with ARAP1.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.

Similarity:
Contains 1 death domain.
Contains 3 TNFR-Cys repeats.

SWISS:
O00220

Gene ID:
8797

Database links:

Entrez Gene: 8797 Human

SwissProt: O00220 Human



产品图片
Sample:
Lane 1: Human Jurkat cell lysates
Lane 2: Human A549 cell lysates
Lane 3: Human HUVEC cell lysates
Lane 4: Human HeLa cell lysates
Primary: Anti-TNFRSF10A (bs-0591R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50 kDa
Observed band size: 60 kDa
Sample:
K562(Human) Cell Lysate at 40 ug
Primary: Anti- DR4 (bs-0591R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 48 kD
Observed band size: 50 kD
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