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Phospho-GLUT4 (Ser488) Recombinant Rabbit mAb (bsm-62861R)  
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25ul/800.00元
50ul/1400.00元
100ul/2500.00元
大包装/询价
产品编号 bsm-62861R
英文名称 Phospho-GLUT4 (Ser488) Recombinant Rabbit mAb
中文名称 磷酸化葡萄糖转运蛋白4重组兔单抗
别    名 insulin-responsive; Glucose transporter GLUT 4; Glucose transporter type 4; Glucose transporter type 4 insulin responsive; GLUT4; Insulin responsive glucose transporter type 4; SLC2A4; Solute carrier family 2 member 4.  
抗体来源 Rabbit
克隆类型 Recombinant
克 隆 号
交叉反应 Human,Mouse,Rat
产品应用 WB=1:1000-1:2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 55 kDa
检测分子量 45
性    状 Liquid
免 疫 原 A synthesized peptide derived from human GLUT4 around the phosphorylation site of S488: HRTP-pS-LLE 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
保存条件 Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.

SWISS:
P14672

Gene ID:
6517

葡萄糖转运蛋白-4是一种十分重要的葡萄糖转运体,与胰岛素抵抗和2型糖尿病密切相关.葡萄糖转运蛋白4在细胞内部和细胞膜之间循环流动.实现对葡萄糖的转运需要葡萄糖转运蛋白4自身的转位和活化.葡萄糖转运蛋白4与肥胖、肿瘤相关联. GLUT-2和GLUT-4蛋白这两个葡萄糖运载体的研究对于糖尿病的胰岛素释放障碍和胰岛素抵抗有重要意义.
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