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Sex hormone binding globulin (SHBG) is a glycoprotein synthesized by the liver. Circulating androgen and estrogen concentrations influence SHBG synthesis. Elevated testosterone, for example, causes SHBG synthesis to decrease, whereas high estrogen stimulates SHBG production. The regulation of SHBG synthesis, combined with SHBG's higher affinity for testosterone, impacts bioavailable testosterone levels. SHBG binds up to 98 percent of the steroid hormones in the blood including 5a-dihydrotestosterone (DHT), testosterone and androstenediol with particularly high affinity, and estradiol and estrone with slightly lower affinity.
性激素结合球蛋白(SHBG),又称睾酮—雌二醇结合球蛋白。
SHBG是一运输性激素的载体，它在性激素人作用过程中以及在各种生理病理情况下都有一定的变化和意义。
SHBG是由母体肝脏产生的循环类固醇类结合球蛋白，执行载体蛋白的功能，胰岛素是肝脏合成SHBG的强大的抑制因子，胰岛素抑制效应的主要作用点在于竞争性刺激肝脏SHBG的产生，因而SHBG减少是高胰岛素血症、胰岛素抵抗的标志。
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