HSP70是一类分子伴侣,可以调控Tau、α-突触核蛋白、TDP-43、朊蛋白和多聚谷氨酰胺蛋白的代谢进程,抑制神经退行性疾病中错误折叠蛋白质的聚集和毒性作用。
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抗体介绍
Beclin-1是自噬中的重要角色,阿尔兹海默症早期,Beclin-1在脑部病变区域中的表达是呈下降趋势的,,研究表明该蛋白的表达会减少细胞内外的淀粉样病变,而表达减少则会增加神经元内淀粉样蛋白的聚集。因此,增加beclin-1水平可能成为潜在的AD的治疗方案。文献引用:(20篇)
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