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Cat. Number:

bs-0260R-AF488

Quantity size:

100ul

Concentration:

1mg/ml  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Insulin receptor binds insulin and has a tyrosine-protein kinase activity. It also has catalytic activity: ATP + a protein tyrosine = ADP + proteintyrosine phosphate. Tetramer of 2 alpha and 2 beta chains linked by disulfidebonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Interacts with SORBS1 but dissociates from it following insulin stimulation. [subcellular location] Type I membrane protein. Belongs to the Tyr protein kinase family. Insulin receptor subfamily.

Also known as:

CD220; CD220 antigen; HHF5; HIR A; INSR alpha; INSR; Insulin receptor; Insulin receptor subunit alpha; IR; INSR_HUMAN.

Specificity:

Storage:

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Application:

Excitation spectrum: 495nm
Emission spectrum: 519nm
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.