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Rabbit  Anti-GALR2/Cy3
Cat. Number:
bs-11527R-Cy3
Quantity size:
100ul
Concentration:
1mg/ml  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The 387 amino acid protein galanin receptor-2 (GALR2) protein belongs to a family of G protein-coupled receptors that specifically bind galanin, a neuropeptide distributed throughout the central and peripheral nervous system, the pituitary gland, the gastrointestinal tract and in the endocrine and exocrine pancreas (1-3). GALR2 mRNA is abundant in parvocellular paraventricular nuclei, but in contrast to GALR1, is not expressed in magnocellular neurons or in supraoptic nuclei. Like GALR1 mRNA, GALR2 mRNA is expressed in the POMC neurons, dorsomedial nucleus, arcuate nucleus and in restricted peripheral tissue, with highest mRNA levels in human small intestine (2-5). Galanin-like peptide (GALP) is a putative endogenous ligand for GALR2 (2). Binding of GALP to GALR2 results in increased GTPgS binding to the membrane-bound GALR2 (6). GALR2 is therefore a receptor that mediates important functions of galanin in the hypothalamic-pituitary axis, plays a role in hippocampal and cerebellar function (7) and mediates jejunal contraction (8).
Also known as:
GAL2-R; GAL2R; Galanin receptor 2; Galanin receptor type 2; GALNR2; GALR-2; GALR2; GALR2_HUMAN; MGC125983; MGC125984.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: (predicted: )
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Immunogen: KLH conjugated synthetic peptide derived from human GALR2 (51-150aa).
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Predicted Molecular Weight: 42kDa.
Storage:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Application:

Excitation spectrum: 514nm,552nm
Emission spectrum: 570nm
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.