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产品编号:

bsk12056

产品规格:

96T    

保存条件:

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)

别名:

CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, C-X-C motif chemokine ligand 12

种属:

Mouse

线性范围:

46.90-3,000 pg/mL

应用范围:

S/P/CC

检测限:

25 pg/mL

产品介绍:

The stromal cell-derived factor 1 (SDF1), also known as C-X-C motif chemokine 12 (CXCL12), is a chemokine protein that in humans is encoded by the CXCL12 gene on chromosome 10.It is ubiquitously expressed in many tissues and cell types.Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the chemokine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF, or IL1. The chemokines are characterized by the presence of 4 conserved cysteines that form 2 disulfide bonds. They can be classified into 2 subfamilies. In the CC subfamily, the cysteine residues are adjacent to each other. In the CXC subfamily, they are separated by an intervening amino acid. The SDF1 proteins belong to the latter group.CXCL12 signaling has been observed in several cancers.The CXCL12 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.