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Rabbit
Anti-NNT1/BSF3/PE-Cy3
Cat. Number:
bs-19304R-PE-Cy3
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Also known as:
B cell stimulating factor 3;
B-cell-stimulating factor 3;
BSF 3;
BSF-3;
BSF3;
Cardiotrophin like cytokine;
Cardiotrophin like cytokine factor 1;
Cardiotrophin-like cytokine factor 1;
CISS 2;
CISS2;
CLC;
CLCF 1;
Clcf1;
CLCF1_HUMAN;
Cold induced sweating syndrome 2;
CRLF 1 associated cytokine like factor 1;
CRLF1 associated cytokine like factor 1;
Neurotrophin 1;
Neurotrophin 1/B cell stimulating factor 3;
Neurotrophin1;
NNT 1;
NNT-1;
Novel neurotrophin 1;
Novel neurotrophin-1;
NR 6;
NR6.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with:
(predicted: )
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Immunogen: KLH conjugated synthetic peptide derived from human NNT1/BSF3.
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Predicted Molecular Weight: 22kDa.
Storage:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Application:
Excitation spectrum: 488nm,532nm,561nm
Emission spectrum: 578nm
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.