Host: Rabbit

Target Protein: ACVRL1

IR: Immunogen Range:21-120/503

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 94

Swiss Prot: P37023

Source: KLH conjugated synthetic peptide derived from human ACVRL1:21-120/503 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.