Host: Rabbit

Target Protein: phospho-SCNN1B (Ser633)

IR: Immunogen Range:IE(p-S)D

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 6338

Swiss Prot: P51168

Source: KLH conjugated Synthesised phosphopeptide derived from human SCNN1B around the phosphorylation site of Ser633:IE(p-S)D 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: SCNN1B is a subunit of the epithelial sodium channel, ENaC. ENac has high sodium selectivity, low conductance, and amiloride sensitivity. The functional channel of ENaC is composed of at least 3 subunits, alpha (SCNN1A), beta (SCNN1B), and gamma (SCNN1G). The 3 subunits show sequence similarities to one another, indicating descent from a common ancestral gene. Each encodes a protein containing 2 transmembrane domains, with intracellular amino and carboxyl termini.