Host: Rabbit

Target Protein: NF1

IR: Immunogen Range:2701-2839/2839

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 4763

Swiss Prot: P21359

Source: KLH conjugated synthetic peptide derived from human Neurofibromin 1:2701-2839/2839 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008].