Host: Rabbit
Target Protein: Phospho-LRP6 (Thr1479)
IR: Immunogen Range:KG(p-T)YF
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 4040
Swiss Prot: O75581
Source:
KLH conjugated Synthesised phosphopeptide derived from human LRP6 around the phosphorylation site of Thr1479:KG(p-T)YF
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009].
Size: 200ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=0.2ug/test, ELISA=1:5000-10000
Cross Reactive Species: Human,Mouse (predicted: Dog,Pig,Cow,Horse,Rabbit,GuineaPig)
For research use only. Not intended for diagnostic or therapeutic use.