Host: Rabbit
Target Protein: TSEN15/C1orf19
IR: Immunogen Range:51-150/171
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 116461
Swiss Prot: Q8WW01
Source: KLH conjugated synthetic peptide derived from human C1orf19/SEN15:51-150/171
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: SEN15, also known as TSEN15 (tRNA-splicing endonuclease subunit Sen15) or C1orf19, is a nuclear protein that plays a role in tRNA splicing. Widely expressed with highest expression in testis and uterus, SEN15 is a non-catalytic subunit of the multi-protein tRNA-splicing endonuclease complex. The endonuclease complex is responsible for identifying and cleaving pre-tRNA at both 5’ and 3’ splice sites, thereby releasing introns and free tRNA molecules with 2',3' cyclic phosphates and 5'-OH termini. In addition to its role in pre-tRNA splicing, the endonuclease complex participates in mRNA processing and, via its association with pre-mRNA processing factors, is thought to link pre-tRNA and pre-mRNA splicing events. As a subunit of the complex, SEN15 participates in protein expression and, ultimately, cell growth and division.
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, ELISA=1:5000-10000
Cross Reactive Species: Human,Mouse,Rat (predicted: Dog,Pig,Cow,Horse,Sheep)
For research use only. Not intended for diagnostic or therapeutic use.