Host: Rabbit
Target Protein: CDC123
IR: Immunogen Range:101-200/336
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 8872
Swiss Prot: O75794
Source: KLH conjugated synthetic peptide derived from human CDC123/C10orf7:101-200/336
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Required for S phase entry of the cell cycle.The eukaryotic cell division cycle consists of a number of gene-controlled sequences that involve cyclin dependent kinases (Cdks) and cell division control (Cdc) proteins. Cdc123 (Cell division cycle protein 123), also known as D123, is a 336 amino acid cytoplasmic protein that is involved in cell cycle control. Widely expressed with high expression in thymus, spleen, ovary, testis, small intestine and leukocytes, Cdc123 functions to destabilize Chfr (checkpoint with forkhead and ring finger domain) proteins which, when accumulated, block the G to S phase transition. Cdc123 prevents the Chfr proteins from collecting in the cell, thereby allowing the cell to enter the S phase. Due to its role in cell cycle control, Cdc123 is thought to be a basal marker for luminal breast cancers.
Size: 200ul
Concentration: 1mg/ml
Applications: Flow-Cyt=1μg/Test, ELISA=1:5000-10000
Cross Reactive Species: Human (predicted: Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep)
For research use only. Not intended for diagnostic or therapeutic use.