Host: Rabbit

Target Protein: REC8

IR: Immunogen Range:22-120/547

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 9985

Swiss Prot: O95072

Source: KLH conjugated synthetic peptide derived from human REC8:22-120/547 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.