Host: Rabbit

Target Protein: Natriuretic Peptide Receptor B

IR: Immunogen Range:101-200/1047

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 4882

Swiss Prot: P20594

Source: KLH conjugated synthetic peptide derived from human NPR-B:101-200/1047 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: NPR2 encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand binding domain, a single membrane spanning region, and intracellularly a protein kinase homology domain), a helical hinge region involved in oligomerization, and a carboxyl terminal guanylyl cyclase catalytic domain. NPR2 is the primary receptor for C type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity.