Host: Rabbit

Target Protein: Plexin A2

IR: Immunogen Range:1251-1400/1894

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5362

Swiss Prot: O75051

Source: KLH conjugated synthetic peptide derived from human Plexin A2:1251-1400/1894 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Plexin A2 is a coreceptor for SEMA3A and is necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. This coreceptor plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin in which the plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.