Host: Rabbit
Target Protein: BLNK
IR: Immunogen Range:301-400/456
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 29760
Swiss Prot: Q8WV28
Source: KLH conjugated synthetic peptide derived from human BLNK:301-400/456
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012].
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, Flow-Cyt=1μg /test, ELISA=1:5000-10000
Cross Reactive Species: Mouse,Human (predicted: Rabbit,Horse,Cow,Pig,Dog,Rat)
For research use only. Not intended for diagnostic or therapeutic use.