Host: Rabbit
Target Protein: Phospho-Bcr (Tyr177)
IR: Immunogen Range:PF(p-Y)VN
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 613
Swiss Prot: P11274
Source: KLH conjugated Synthesisedphosphopeptide derived from human Bcr around the phosphorylation site of Tyr177:PF(p-Y)VN
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.
Size: 100ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000
Cross Reactive Species: (predicted: Human,Mouse,Rat,Pig,Rabbit,GuineaPig)
For research use only. Not intended for diagnostic or therapeutic use.