Host: Rabbit

Target Protein: Phospho-Bcr (Tyr177) Rabbit pAb

IR: Immunogen Range:PF(p-Y)VN

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 613

Swiss Prot: P11274

Source: KLH conjugated Synthesisedphosphopeptide derived from human Bcr around the phosphorylation site of Tyr177:PF(p-Y)VN 

Purification: affinity purified by Protein A

Storage: 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Background: The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.