Host: Rabbit
Target Protein: TGF beta Receptor II
IR: Immunogen Range:421-520/567
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 7048
Swiss Prot: P37173
Source: KLH conjugated synthetic peptide derived from human TGF beta Receptor II :421-520/567
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
Size: 50ul
Concentration: 1mg/ml
Applications: IHC-P=1:100-500, ELISA=1:5000-10000
Cross Reactive Species: Human (predicted: Sheep,Rabbit,Horse,Cow,Pig,Dog,Rat,Mouse)
For research use only. Not intended for diagnostic or therapeutic use.