bs-3021R [Primary Antibody]
Rabbit  Anti-phospho-ALK (Tyr1278 + Tyr1282 + Tyr1283) Rabbit pAb  Polyclonal Antibody
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Host: Rabbit

Target Protein: phospho-ALK (Tyr1278 + Tyr1282 + Tyr1283) Rabbit pAb

IR: Immunogen Range:DI(p-Y)RAS(p-Y)(p-Y)RK

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 238

Swiss Prot: Q9UM73

Source: KLH conjugated Synthesised phosphopeptide derived from human ALK around the phosphorylation site of Tyr1278/1282/1283:DI(p-Y)RAS(p-Y)(p-Y)RK 

Purification: affinity purified by Protein A

Storage: 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Background: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), LK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011].

Size: 50ul

Concentration: 1mg/ml

Applications: Flow-Cyt=1μg /test

Cross Reactive Species: Human (predicted: Mouse,Rat,Cow,Chicken,Dog,Horse)

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES
Blank control(blue): Jurkat (fixed with 2% paraformaldehyde (10 min)). Primary Antibody:Rabbit Anti-phospho-ALK (Tyr1278 + Tyr1282 + Tyr1283) antibody(bs-3021R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
 
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