Host: Rabbit
Target Protein: ADAR1
IR: Immunogen Range:151-250/1226
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 103
Swiss Prot: P55265
Source: KLH conjugated synthetic peptide derived from human DRADA:151-250/1226
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: ADAR1 converts adenosine to inosine in dsRNA, which destabilizes the dsRNA helix. This activity is important for various functions like site-specific RNA editing of transcripts of the glutamate receptors and modifying viral RNA genomes (which may be responsible for hypermutation of certain negative-stranded viruses, e.g., measles virus). ADAR1 also binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. This protein is ubiquitously expressed, with the highest levels being found in brain and lung.
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:25, IF=1:100-500, ELISA=1:5000-10000
Cross Reactive Species: Human
For research use only. Not intended for diagnostic or therapeutic use.