Host: Mouse

Target Protein: CEA(ready to use)

IR: Immunogen Range:full length

Clonality: Monoclonal

Isotype: IgG2b

Entrez Gene: 4680

Swiss Prot: P40199

Source: Human Carcino Embryonic Antigen:full length 

Purification: affinity purified by Protein G

Storage: 0.01M PBS(pH7.4) with 1% BSA and 0.1% Proclin300 Store at 2-8 °C for one year. Avoid repeated freeze/thaw cycles.

Background: CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glyco-protein (PSG 1-PSG 11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.