Host: Mouse
Target Protein: CD146
IR: Immunogen Range:
Clonality: Monoclonal
Isotype: IgG
Entrez Gene: 4162
Swiss Prot: P43121
Source: KLH conjugated synthetic peptide derived from human CD146:
Purification: affinity purified by Protein G
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: MCAM (MUC18 antigen, CD146), a member of the immuoglobulin superfamily, is an intrinsic membrane glycoprotein of 110-120 kDa found on the surface of endothelial cells, bone marrow fibroblasts and various melanomas. MCAM (Melanoma adhesion molecule) has been used as a marker of tumor progression in human melanoma because expression in those tumors correlates strongly with poor prognosis and the development of metastic disease. In addition, a number of human T, B and myeloid leukemic cell lines seem to express MCAM. The close structural relationship with N-CAM and related molecules suggests that MCAM may be also a developmentally regulated cell adhesion.
Size: 50ul
Concentration: 0.5mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, Flow-Cyt=1µl/Tests
Cross Reactive Species: (predicted: Human)
For research use only. Not intended for diagnostic or therapeutic use.