Host: Mouse

Target Protein: human CD15 (SSEA-1)

IR: Immunogen Range:

Clonality: Monoclonal

Isotype: Mouse Ig1, k

Entrez Gene: /

Swiss Prot: /

Source: Mouse F9 Teratocarcinoma Stem Cells (X-irradiated): 

Purification: Affinity purified by Protein G

Storage: 0.01M TBS(pH=7.4) Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Background: The CD15 antibody reacts with mouse and human Stage-Specific Embryonic Antigen-1 (SSEA-1). It is a Lewis blood group related carbohydrate antigen, also known as X-hapten, Lewis X, 3-FAL, 3-fucosyl-N-acetyllactosamine, or CD15. The expression pattern of SSEA-1 antigen is different in humans than in mice. In mice, SSEA-1 is expressed on embryonic stem cells (ES), embryonal carcinoma cells (EC), 8-cell to blastocyst embryos, and a subset of embryonic inner cell mass. The expression on murine ES cells is decreased upon differentiation. In humans, however, SSEA-1 is not found on undifferentiated ES cells, but its expression is upregulated along with differentiation. CD15 is highly expressed on adult human granulocytes. It has been reported that SSEA-1 plays a role in cell adhesion and regulation of cell differentiation.