bs-18955R [Primary Antibody]
Rabbit  Anti-MLLT6 Rabbit pAb  Polyclonal Antibody
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Host: Rabbit

Target Protein: MLLT6 Rabbit pAb

IR: Immunogen Range:1001-1093/1093

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 4302

Swiss Prot: P55198

Source: KLH conjugated synthetic peptide derived from human MLLT6:1001-1093/1093 

Purification: affinity purified by Protein A

Storage: 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Background: The gene encoding the Mixed-Lineage Leukemia (MLL) proteins is located on chromosome 11q23. Chromosomal translocations involving band 11q23 result in rogue activator proteins that are associated with approximately 10% of patients with acute lymphoblastic leukemia (ALL) and 5% of patients with acute myeloid leukemia (AML). Most patients affected are less than 1 year of age. The gene encoding MLLT6, also known as mixed-lineage leukemia translocated to 6 or AF17, is located on chromosome 17q12 and encodes a 1093 amino acid protein that is thought to be involved in the translocations on chromosome 11q23. Localized to the nucleus, MLLT6 contains a leucine-zipper dimerization motif located 3-prime of the fusion point and a cysteine-rich domain at the C-terminus. MLLT6 is thought to play a role in ALL by repressing the activity of the truncated ALL1 protein.

Size: 50ul

Concentration: 1mg/ml

Applications: IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000

Cross Reactive Species: (predicted: Human,Mouse,Rat,Rabbit,Sheep,Cow,Dog,Horse)

For research use only. Not intended for diagnostic or therapeutic use.

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