Host: Rabbit

Target Protein: SPOCD1

IR: Immunogen Range:361-450/1216

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 90853

Swiss Prot: Q6ZMY3

Source: KLH conjugated synthetic peptide derived from human SPOCD1:361-450/1216 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: SPOCD1 is a 1,216 amino acid protein that contains one SPOC domain and one TFIIS central domain. SPOCD1 exists as five alternatively spliced isoforms, with isoform 1 showing expression in lung. The gene that encodes SPOCD1 contains 25,630 bases and maps to human chromosome 1p35.2. Spanning about 260 million base pairs and making up 8% of the human genome, chromosome 1 is the largest human chromosome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1 and aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.