Host: Rabbit

Target Protein: Claudin 22

IR: Immunogen Range:101-180/220

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 53842

Swiss Prot: Q8N7P3

Source: KLH conjugated synthetic peptide derived from human Claudin 22:101-180/220 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The claudin superfamily consists of many structurally related proteins that are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. It is suggested that the claudin family of proteins regulate transport through tight junctions via differential discrimination for solute size and charge. Claudin expression is often highly restricted to specific regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-22, also known as CLDN22, is a 220 amino acid member of the claudin family that participates in tight junction-specific obliteration of the intercellular space through calcium-independent cell-adhesion activity.