Host: Rabbit

Target Protein: phospho-CD130/gp130 (Ser782) Rabbit pAb

IR: Immunogen Range:SE(p-S)TQ

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3572

Swiss Prot: P40189

Source: KLH conjugated synthesised phosphopeptide derived from human gp130 around the phosphorylation site of Ser782:SE(p-S)TQ 

Purification: affinity purified by Protein A

Storage: 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Background: CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.