Host: Rabbit

Target Protein: GJC1

IR: Immunogen Range:121-220/294

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 125111

Swiss Prot: Q8N144

Source: KLH conjugated synthetic peptide derived from human Connexin 31.9:121-220/294 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The connexin family of proteins form hexameric complexes, called connexons, that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane ?helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains; the transmembrane and extracellular regions. Connexin 31.9, also known as GJD3 (Gap junction delta-3 protein), is a 294 amino acid protein that interacts with ZO-1, a tight junction protein. Connexin 31.9 is expressed in heart, brain, kidney, spleen, lung, testis, colon and vascular smooth muscle cells. There are two isoforms of connexin 31.9 that are produced as a result of alternative splicing events.