Host: Rabbit
Target Protein: GGA2
IR: Immunogen Range:161-260/613
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 23062
Swiss Prot: Q9UJY4
Source: KLH conjugated synthetic peptide derived from human GGA2:161-260/613
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: A family of proteins, the GGAs (Golgi-localized, g-adaptin ear-containing, ARF-binding proteins) sequences that showed significant homology to the carboxy-terminal 'ear' domain of g-adaptin. Members of the GGA family (GGA1,GGA2 (also known as VEAR or VHS domain and ear domain of g-adaptin) and GGA3) are ubiquitous coat proteins that facilitate the trafficking of proteins between the trans-Golgi network and the lysosome. However, unlike g-adaptin, the GGAs are not associated with clathrin-coated vesicles or with any of the components of the AP-1 complex. GGA1 and GGA2 are also not associated with each other, although they colocalize on perinuclear membranes. GGA2 shares 45% amino acid sequence identity with GGA1 and 35% with GGA3. In addition to being involved in heterotypic vesicle/suborganelle interactions associated with the Golgi complex, GGA2 may have a tissue-specific function and is highly expressed in kidney, muscle and heart. Furthermore, the VHS domain of GGA2 binds to the acidic cluster-di-leucine motif in the cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR) and this is important for lysosomal enzyme targeting.
Size: 200ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500, ELISA=1:5000-10000
Cross Reactive Species: Rat (predicted: Human,Mouse,Dog,Pig,Cow,Rabbit,Sheep)
For research use only. Not intended for diagnostic or therapeutic use.