Host: Rabbit

Target Protein: phospho-c-Kit (Tyr568 + Tyr570) Rabbit pAb

IR: Immunogen Range:NN(p-Y)V(p-Y)ID

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3815

Swiss Prot: P10721

Source: KLH conjugated synthesised phosphopeptide derived from human c-Kit around the phosphorylation site of Tyr568 + Tyr570:NN(p-Y)V(p-Y)ID 

Purification: affinity purified by Protein A

Storage: 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Background: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.