Host: Rabbit

Target Protein: phospho-ZFP36L1 (Ser92)

IR: Immunogen Range:SF(p-S)EG

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 677

Swiss Prot: Q07352

Source: KLH conjugated synthesised phosphopeptide derived from human ZFP36L1 around the phosphorylation site of Ser92:SF(p-S)EG 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: EGF response factor 1 is a zinc-binding protein encoded by the immediate-early response gene, Zfp-36. TIS11B, a relative of TTP, localizes to the nucleus and may function as a transcription factor involved in regulating the growth factor response. It is an evolutionarily conserved protein containing two C3H1-type zinc fingers and a repeating cys-his motif. TIS11B is an mRNA binding protein and is known to interact with the 3’-untranslated region of VEGF mRNA, thereby decreasing its stability. This suggests that TIS11B is a potential target in antiangiogenic therapy. In addition, TIS11B may also be an important regulator of myogenesis, as its expression is upregulated during murine myoblast differentiation.