Host: Rabbit

Target Protein: phospho-Brk (Tyr447)

IR: Immunogen Range:TS(p-Y)EN

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5753

Swiss Prot: Q13882

Source: KLH conjugated synthesised phosphopeptide derived from human Brk around the phosphorylation site of Tyr447:TS(p-Y)EN 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: This protein encoded is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. Its presence in the nucleus appears to be linked to suppression of tumor progression. The encoded protein has been shown to undergo autophosphorylation.