bs-11990R [Primary Antibody]
Rabbit  Anti-HUNK Rabbit pAb  Polyclonal Antibody
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Host: Rabbit

Target Protein: HUNK Rabbit pAb

IR: Immunogen Range:71-115/714

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 30811

Swiss Prot: P57058

Source: KLH conjugated synthetic peptide derived from human Serine/threonine-protein kinase MAK-V:71-115/714 

Purification: affinity purified by Protein A

Storage: 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Background: The HUNK (hormonally upregulated Neu-associated kinase) protein, also designated MAK-V in mouse, has been identified as a novel SNF1-related serine/threonine kinase. The human HUNK gene localizes to chromosome 21q22 and encodes a protein with nucleocytoplasmic distribution and localizes to the centrosome. Overexpression of the HUNK protein associates with approximately 50% of breast carcinomas, and may provide diagnostic-prognostic value as a molecular marker. Serine/threonine-protein kinase SNF1-like kinase 2 (SIK) phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, which may modulate the efficiency of insulin signal transduction. SIK is activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-α and CAB39.

Size: 200ul

Concentration: 1mg/ml

Applications: WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000

Cross Reactive Species: (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow)

For research use only. Not intended for diagnostic or therapeutic use.

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