Host: Rabbit

Target Protein: phospho-SNAIL + SLUG (Ser246)

IR: Immunogen Range:TF(p-S)RM

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 6615

Swiss Prot: O95863

Source: KLH conjugated synthesised phosphopeptide derived from human SNAIL around the phosphorylation site of Ser246:TF(p-S)RM 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin. SLUG is involved in epithelial-mesenchymal transitions (EMT) involving E-cadherin repression which is known to play an important role in tumor progression amd neural tube formation. SLUG also has antiapoptotic activity. Mutations in this gene may be associated with sporadic cases of neural tube defects (referenced from Entrez gene).