Host: Rabbit
Target Protein: NALP3/CIAS1
IR: Immunogen Range:15-120/1036
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 114548
Swiss Prot: Q96P20
Source: KLH conjugated synthetic peptide derived from human Cryopyrin:15-120/1036
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:200-800, Flow-Cyt=2ug/Test, ELISA=1:5000-10000
Cross Reactive Species: Human,Mouse,Rat,Dog
For research use only. Not intended for diagnostic or therapeutic use.