Host: Rabbit
Target Protein: DISP2
IR: Immunogen Range:1101-1200/1401
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 85455
Swiss Prot: A7MBM2
Source: KLH conjugated synthetic peptide derived from human DISP2:1101-1200/1401
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: DISP2 is the second of three known homologs of the D.melanogaster protein Dispatched. It is a multitransmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants. At least two isoforms of DISP2 are known to exist.
Size: 50ul
Concentration: 1mg/ml
Applications: ELISA=1:5000-10000
Cross Reactive Species: (predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse)
For research use only. Not intended for diagnostic or therapeutic use.