Host: Rabbit
Target Protein: phospho-IRE1a (Ser 726)
IR: Immunogen Range:SF(p-S)RR
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 2081
Swiss Prot: O75460
Source: KLH conjugated synthesised phosphopeptide derived from human IRE1a around the phosphorylation site of Ser726 :SF(p-S)RR
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Size: 50ul
Concentration: 1mg/ml
Applications: IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=1ug/test, ELISA=1:5000-10000
Cross Reactive Species: Human,Mouse,Rat (predicted: Dog,Pig,Cow,Horse,Rabbit)
For research use only. Not intended for diagnostic or therapeutic use.